Copper-Catalyzed Benzylic C–H Bond Thiocyanation: Enabling Late-Stage Diversifications
نویسندگان
چکیده
منابع مشابه
Copper-catalyzed nucleophilic trifluoromethylation of benzylic chlorides.
Reactions of primary and secondary benzylic chlorides with trifluoromethyltrimethylsilane in the presence of a catalytic amount of copper(i) thiophene-2-carboxylate (CuTC) have been found to give the corresponding benzylic trifluoromethylated products in good to high yields.
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Direct C-F functionalization of benzylic sp(3) C-H bonds is a synthetic challenge that has yet to be propitiously overcome. A mild, one-pot synthesis of monofluorinated benzylic substrates is reported with commercially available iron(II) acetylacetonate and Selectfluor in good to excellent yields and selectivity. A convenient route to β-fluorinated products of 3-aryl ketones is also highlighted...
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Benzylic alcohols and ethers are common subunits in bioactive molecules, as well as useful intermediates in organic chemistry. In this Communication, we describe a new approach to the enantioselective synthesis of benzylic ethers through the chiral phosphine-catalyzed coupling of two readily available partners, γ-aryl-substituted alkynoates and alcohols, under mild conditions. In this process, ...
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ژورنال
عنوان ژورنال: CCS Chemistry
سال: 2020
ISSN: 2096-5745
DOI: 10.31635/ccschem.020.202000435